Immune system parameters in chronic opisthorchiasis patients related to genes polymorphisms associated with developing ischemic heart disease

The aim of the study was to identify a relationship between gene polymorphisms associated with developing coronary heart disease and pathogenetic features opisthorchiasis invasion. There were compared laboratory parameters assessing immune system functioning (lymphocyte immunophenotyping evaluated by flow cytometry, serum immunoglobulin cytokine concentrations, non-specific resistance indices) in patients chronic (caused Opisthorchis felineus) various genotypes with/without mutations loci predisposition disease. It found that invasion leads altered response bearing genes encoding adenosine monophosphate deaminase 1, hypoxia induced factor 1 alpha, apolipoprotein E affecting relevant protein functions those without minor alleles. Upon that, carrying mutation gene, turned out have lowered cellular (decreased count cytotoxic lymphocytes) humoral immunity A level). Patients rare allele hypoxia-induced alpha featured activated adaptive reduced activation innate immunity. Moreover, mutated coupled decreased activity response, which exacerbates course invasion, whereas rs1333049 polymorphism cyclin-dependent kinase inhibitor results no significantly response. Thus, gene-related dysfunction certain proteins may allow elicit multidirectional changes so approaching normal range diverse immune-related during parasitic not necessarily be interpreted as “protective” effect exerted any polymorphisms. most prominent detected case factor-induced hypoxia-1 gene. data obtained suggest aforementioned genetic predispose manifestation clinical forms.